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0-Choose a niche which contains high CPC keywords. My favorite’s niches: 
Investment – real estate – jobs – scholarship – education – health – animals.
1- Use High CPC keywords in your article. Just go to Google keyword Planner and you will 
find a lot of keywords related to your niche that have high CPC.
2- Create a sub-domain with a high CPC keyword to promote your Winning Article. 
3- Use Long articles from 800 to 5.000.
4- Put High CPC keywords in ALT image to help Google Adsense Algorithm know more 
about your article in order to increase CPC.
5- Target countries like USA, CANADA, AUSTRALIA, GERMANY, UK, NEWZELAND, SWEDEN... 
6- Target Desktop users
7- Buy traffic from high quality network. Google prefers Native ads (TABOOLA – 
REVCONTENT….) in comparison with other networks like Facebook Ads. 
8- Give to your Visitors High Quality Content (Value) = they will still a lot of time reading 
your Content = Bounce Rate ↘ =CPC ↗↗↗
9- If you target the right audience, you will get best CPC in your network and also increase 
your CPC in GOOGLE ADSENSE.
You can be profitable targeting Tier countries like Nigeria, Brazil, and Mexico. You can also 
find a successful article by targeting mobile and Tablet users. This is why you have to test all 
this in the beginning than keep countries, devices and ages that give you the best ROI%.
Just you have to give time to the testing. Then, you pass to analyze your campaign.
-    If the CPC is low than 0.3-0.5 dollar, you have to increase it. I prefer CPC up to 0.5% 
to get an ROI% BETWEEN 400% and 800%0
-    If the CTR% is low than 5%, you have to increase it to 4% to 8%.
-    If CPC in fb ads or native ads is up to 0.06-0.08 you have to decrease it to 0.02-0.03 
dollars
-    If CTR% in fb ads or native ads is low than 0.5% you have to increase it to up to 1%.

https://ads.google.com/home/tools/keyword-planner/